\begin{thebibliography}{10} \bibitem{Kutateladze:2010jz} Kutateladze TG. \newblock {Translation of the phosphoinositide code by PI effectors}. \newblock Nat Chem Biol. 2010;6(7):507--513. \bibitem{Vogler:2008ch} V{\"o}gler O, Barcel{\'o} JM, Ribas C, Escrib{\'a} PV. \newblock {Membrane interactions of G proteins and other related proteins}. \newblock Biochimica et Biophysica Acta (BBA) - Biomembranes. 2008;1778(7-8):1640--1652. \bibitem{Cullen:2008kv} Cullen PJ. \newblock {Endosomal sorting and signalling: an emerging role for sorting nexins}. \newblock Nat Rev Mol Cell Biol. 2008;9(7):574--582. \bibitem{Inaba:2016cb} Inaba T, Kishimoto T, Murate M, Tajima T, Sakai S, Abe M, et~al. \newblock {Phospholipase C$\beta$1 induces membrane tubulation and is involved in caveolae formation.} \newblock Proc Natl Acad Sci U S A. 2016;113(28):7834--7839. \bibitem{Itoh:2005cp} Itoh T, Erdmann KS, Roux A, Habermann B, Werner H, De~Camilli P. \newblock {Dynamin and the Actin Cytoskeleton Cooperatively Regulate Plasma Membrane Invagination by BAR and F-BAR Proteins}. \newblock Developmental Cell. 2005;9(6):791--804. \bibitem{Lemmon:2008kt} Lemmon MA. \newblock {Membrane recognition by phospholipid-binding domains}. \newblock Nat Rev Mol Cell Biol. 2008;9(2):99--111. \bibitem{Cho:2005bq} Cho W, Stahelin RV. \newblock {Membrane-Protein Interactions in Cell Signaling and Membrane Trafficking}. \newblock Annu Rev Bioph Biom. 2005;34(1):119--151. \bibitem{Johnson:1999wc} Johnson JE, Cornell RB. \newblock {Amphitropic proteins: regulation by reversible membrane interactions (review)}. \newblock Mol Membr Biol. 1999;. \bibitem{MulgrewNesbitt:2006dy} Mulgrew-Nesbitt A, Diraviyam K, Wang J, Singh S, Murray P, Li Z, et~al. \newblock {The role of electrostatics in protein-membrane interactions.} \newblock Biochim Biophys Acta. 2006;1761(8):812--826. \bibitem{Lazaridis:2003wu} Lazaridis T. \newblock {Effective energy function for proteins in lipid membranes - Lazaridis - 2003 - Proteins: Structure, Function, and Bioinformatics - Wiley Online Library}. \newblock Proteins: Structure. 2003;. \bibitem{Lomize:2007gm} Lomize AL, Pogozheva ID, Lomize MA, Mosberg HI. \newblock {The role of hydrophobic interactions in positioning of peripheral proteins in membranes}. \newblock BMC Structural Biology. 2007;7:44. \bibitem{Gilbert:2002ja} Gilbert GE, Kaufman RJ, Arena AA, Miao H, Pipe SW. \newblock {Four Hydrophobic Amino Acids of the Factor VIII C2 Domain Are Constituents of Both the Membrane-binding and von Willebrand Factor-binding Motifs}. \newblock J Biol Chem. 2002;277(8):6374--6381. \bibitem{Gamsjaeger:2005jd} Gamsjaeger R, Johs A, Gries A, Gruber HJ, Romanin C, Prassl R, et~al. \newblock {Membrane binding of $\beta$ 2-glycoprotein I can be described by a two-state reaction model: an atomic force microscopy and surface plasmon resonance study}. \newblock Biochem J. 2005;389(3):665--673. \bibitem{Ford:2002if} Ford MGJ, Mills IG, Peter BJ, Vallis Y, Praefcke GJK, Evans PR, et~al. \newblock {Curvature of clathrin-coated pits driven by epsin.} \newblock Nature. 2002;419(6905):361--366. \bibitem{BalaliMood:2009cv} Balali-Mood K, Bond PJ, Sansom MSP. \newblock {Interaction of Monotopic Membrane Enzymes with a Lipid Bilayer: A Coarse-Grained MD Simulation Study {\dag}}. \newblock Biochemistry. 2009;48(10):2135--2145. \bibitem{Yang:2015fd} Yang B, Pu M, Khan HM, Friedman L, Reuter N, Roberts MF, et~al. \newblock {Quantifying Transient Interactions between BacillusPhosphatidylinositol-Specific Phospholipase-C and Phosphatidylcholine-Rich Vesicles}. \newblock JACS. 2015;137(1):14--17. \bibitem{Miller:1987un} Miller S, Janin J, Lesk AM, Chothia C. \newblock {Interior and surface of monomeric proteins.} \newblock J Mol Biol. 1987;196(3):641--656. \bibitem{Perisic:1998tv} Perisic O, Fong S, Lynch DE, Bycroft M, Williams RL. \newblock {Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2.} \newblock J Biol Chem. 1998;273(3):1596--1604. \bibitem{Bravo:2001ua} Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, Anderson KE, et~al. \newblock {The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.} \newblock Mol Cell. 2001;8(4):829--839. \bibitem{Scott:1990wf} Scott DL, White SP, Otwinowski Z, Yuan W, Gelb MH, Sigler PB. \newblock {Interfacial catalysis: the mechanism of phospholipase A2.} \newblock Science. 1990;250(4987):1541--1546. \bibitem{Zhang:1995vz} Zhang G, Kazanietz MG, Blumberg PM, Hurley JH. \newblock {Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester.} \newblock Cell. 1995;81(6):917--924. \bibitem{Misra:1999uo} Misra S, Hurley JH. \newblock {Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p.} \newblock Cell. 1999;97(5):657--666. \bibitem{Agasoster:2003bja} Agas{\o}ster AV, Halskau {\O}, Fuglebakk E, Fr{\o}ystein NA, Muga A, Holmsen H, et~al. \newblock {The interaction of peripheral proteins and membranes studied with alpha-lactalbumin and phospholipid bilayers of various compositions.} \newblock J Biol Chem. 2003;278(24):21790--21797. \bibitem{Lomize:2011hl} Lomize AL, Pogozheva ID, Mosberg HI. \newblock {Anisotropic solvent model of the lipid bilayer. 1. Parameterization of long-range electrostatics and first solvation shell effects.} \newblock J Chem Inf Model. 2011;51(4):918--929. \bibitem{Lomize:2011iz} Lomize MA, Pogozheva ID, Joo H, Mosberg HI, Lomize AL. \newblock {OPM database and PPM web server: resources for positioning of proteins in membranes}. \newblock Nucleic Acids Res. 2011;40(D1):D370--D376. \bibitem{Petsko:2004wf} Petsko G, Ringe D. \newblock {Protein Structure and Function}. \newblock New Science Press; 2004. \bibitem{Wimley:1996vpa} Wimley WC, White SH. \newblock {Experimentally determined hydrophobicity scale for proteins at membrane interfaces.} \newblock Nat Struct Biol. 1996;3(10):842--848. \bibitem{Wilmot:1988vb} Wilmot CM, Thornton JM. \newblock {Analysis and prediction of the different types of $\beta$-turn in proteins}. \newblock J Mol Biol. 1988;203(1):221--232. \bibitem{Park:2016kw} Park MJ, Sheng R, Silkov A, Jung DJ, Wang ZG, Xin Y, et~al. \newblock {SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins}. \newblock Mol Cell. 2016;62(1):7--20. \bibitem{Fox:2014vx} Fox NK, Brenner SE, Chandonia JM. \newblock {SCOPe: Structural Classification of Proteins{\textemdash}extended, integrating SCOP and ASTRAL data and classification of new structures}. \newblock Nucleic Acids Res. 2014;. \bibitem{Krissinel:2007wq} Krissinel E, Henrick K. \newblock {Inference of macromolecular assemblies from crystalline state}. \newblock J Mol Biol. 2007;. \bibitem{Lomize:2011gj} Lomize AL, Pogozheva ID, Mosberg HI. \newblock {Anisotropic solvent model of the lipid bilayer. 2. Energetics of insertion of small molecules, peptides, and proteins in membranes.} \newblock J Chem Inf Model. 2011;51(4):930--946. \bibitem{Berman:2000fma} Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, et~al. \newblock {The Protein Data Bank}. \newblock Nucleic Acids Res. 2000;28(1):235--242. \bibitem{Velankar:2009he} Velankar S, Best C, Beuth B, Boutselakis CH, Cobley N, Sousa Da~Silva AW, et~al. \newblock {PDBe: Protein Data Bank in Europe}. \newblock Nucleic Acids Res. 2009;38(Database):D308--D317. \bibitem{Jones:2000vm} Jones S, Marin A, Thornton JM. \newblock {Protein domain interfaces: characterization and comparison with oligomeric protein interfaces.} \newblock Protein Eng. 2000;13(2):77--82. \bibitem{TonddastNavaei:2015bm} Tonddast-Navaei S, Skolnick J. \newblock {Are protein-protein interfaces special regions on a protein{\textquoteright}s surface?} \newblock J Chem Phys. 2015;143(24):243149. \bibitem{Hedin:2002eu} Hedin EMK, H{\o}yrup P, Patkar SA, Vind J, Svendsen A, Fransson L, et~al. \newblock {Interfacial Orientation of Thermomyces lanuginosaLipase on Phospholipid Vesicles Investigated by Electron Spin Resonance Relaxation Spectroscopy {\dag}}. \newblock Biochemistry. 2002;41(48):14185--14196. \bibitem{Grauffel:2013uf} Grauffel C, Yang B, He T, Roberts MF, Gershenson A, Reuter N. \newblock {Cation{\textminus}$\pi$ Interactions As Lipid-Specific Anchors for Phosphatidylinositol-Specific Phospholipase C}. \newblock Journal of the {\ldots}. 2013;. \bibitem{Malmberg:2003uk} Malmberg NJ, Van~Buskirk DR, Falke JJ. \newblock {Membrane-Docking Loops of the cPLA2 C2 Domain:  Detailed Structural Analysis of the Protein{\textminus}Membrane Interface via Site-Directed Spin-Labeling - Biochemistry (ACS Publications)}. \newblock Biochemistry. 2003;. \bibitem{Stahelin:2003cv} Stahelin RV, Burian A, Bruzik KS, Murray D, Cho W. \newblock {Membrane Binding Mechanisms of the PX Domains of NADPH Oxidase p40 phox and p47 phox}. \newblock jbcorg. 2003;278(16):14469--14479. \bibitem{Stahelin:uj} Stahelin RV, Long F, Diraviyam K, Bruzik KS, Murray D, Cho W. \newblock {Phosphatidylinositol 3-Phosphate Induces the Membrane Penetration of the FYVE Domains of Vps27p and Hrs}. \newblock J Biol Chem. 2002;277(29):26379--26388. \bibitem{Wang:2001jw} Wang QJ. \newblock {Role of Hydrophobic Residues in the C1b Domain of Protein Kinase C delta on Ligand and Phospholipid Interactions}. \newblock J Biol Chem. 2001;276(22):19580--19587. \bibitem{Stahelin:2003is} Stahelin RV, Long F, Peter BJ, Murray D, De~Camilli P, McMahon HT, et~al. \newblock {Contrasting Membrane Interaction Mechanisms of AP180 N-terminal Homology (ANTH) and Epsin N-terminal Homology (ENTH) Domains}. \newblock J Biol Chem. 2003;278(31):28993--28999. \bibitem{Stahelin:2001cr} Stahelin RV, Cho W. \newblock {Differential Roles of Ionic, Aliphatic, and Aromatic Residues in Membrane{\textminus}Protein Interactions:~ A Surface Plasmon Resonance Study on Phospholipases A 2{\dag}}. \newblock Biochemistry. 2001;40(15):4672--4678. \bibitem{Frazier:2003wf} Frazier AA, Roller CR, Havelka JJ, Hinderliter A. \newblock {Membrane-Bound Orientation and Position of the Synaptotagmin I C2A Domain by Site-Directed Spin Labeling - Biochemistry (ACS Publications)}. \newblock Biochemistry. 2003;. \bibitem{Gerber:2002fp} Gerber SH, Rizo J, Sudhof TC. \newblock {Role of Electrostatic and Hydrophobic Interactions in Ca2+-Dependent Phospholipid Binding by the C2A-Domain From Synaptotagmin I}. \newblock Diabetes. 2002;51(Supplement 1):S12--S18. \bibitem{Rufener:2005ie} Rufener E, Frazier AA, Wieser CM, Hinderliter A, Cafiso DS. \newblock {Membrane-Bound Orientation and Position of the Synaptotagmin C2B Domain Determined by Site-Directed Spin Labeling {\dag}}. \newblock Biochemistry. 2005;44(1):18--28. \bibitem{CorbalanGarcia:2003ba} Corbal{\'a}n-Garc{\'\i}a S, S{\'a}nchez-Carrillo S, Garc{\'\i}a-Garc{\'\i}a J, G{\'o}mez-Fern{\'a}ndez JC. \newblock {Characterization of the Membrane Binding Mode of the C2 Domain of PKC$\varepsilon$ {\dag}}. \newblock Biochemistry. 2003;42(40):11661--11668. \bibitem{Kim:2000em} Kim SW, Quinn-Allen MA, Camp JT, Macedo-Ribeiro S, Fuentes-Prior P, Bode W, et~al. \newblock {Identification of Functionally Important Amino Acid Residues within the C2-Domain of Human Factor V Using Alanine-Scanning Mutagenesis {\dag}}. \newblock Biochemistry. 2000;39(8):1951--1958. \bibitem{Feng:2002fc} Feng J. \newblock {Role of Tryptophan Residues in Interfacial Binding of Phosphatidylinositol-specific Phospholipase C}. \newblock J Biol Chem. 2002;277(22):19867--19875. \bibitem{Feng:2003ik} Feng J, Bradley WD, Roberts MF. \newblock {Optimizing the Interfacial Binding and Activity of a Bacterial Phosphatidylinositol-specific Phospholipase C}. \newblock J Biol Chem. 2003;278(27):24651--24657. \bibitem{Walther:2004ut} Walther M, Wiesner R, Kuhn H. \newblock {Investigations into Calcium-dependent Membrane Association of 15-Lipoxygenase-1}. \newblock J Biol Chem. 2004;. \bibitem{Kohout:2003bs} Kohout SC, Corbal{\'a}n-Garc{\'\i}a S, G{\'o}mez-Fern{\'a}ndez JC, Falke JJ. \newblock {C2 Domain of Protein Kinase C$\alpha$:~ Elucidation of the Membrane Docking Surface by Site-Directed Fluorescence and Spin Labeling {\dag}}. \newblock Biochemistry. 2003;42(5):1254--1265. \bibitem{Goh:2016hv} Goh BC, Wu H, Rynkiewicz MJ, Schulten K, Seaton BA, McCormack FX. \newblock {Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations}. \newblock Biochemistry. 2016; p. acs.biochem.6b00048. \bibitem{BCampos:1998fa} {B Campos}, {Y D Mo}, {T R Mealy}, {C W Li}, {M A Swairjo}, {C Balch}, et~al. \newblock {Mutational and Crystallographic Analyses of Interfacial Residues in Annexin V Suggest Direct Interactions with Phospholipid Membrane Components{\dag},{\ddag}}. \newblock Biochemistry. 1998;37(22):8004--8010. \bibitem{Isas:2004fw} Isas JM, Langen R, Hubbell WL, Haigler HT. \newblock {Structure and Dynamics of a Helical Hairpin that Mediates Calcium-dependent Membrane Binding of Annexin B12}. \newblock J Biol Chem. 2004;279(31):32492--32498. \bibitem{Kutateladze:2001ir} Kutateladze T. \newblock {Structural Mechanism of Endosome Docking by the FYVE Domain}. \newblock Science. 2001;291(5509):1793--1796. \bibitem{Anderluh:2005kk} Anderluh G, Razpotnik A, Podlesek Z, Macek P, Separovic F, Norton RS. \newblock {Interaction of the eukaryotic pore-forming cytolysin equinatoxin II with model membranes: 19F NMR studies.} \newblock J Mol Biol. 2005;347(1):27--39. \bibitem{Shenkarev:2006fg} Shenkarev ZO, Nadezhdin KD, Sobol VA, Sobol AG, Skjeldal L, Arseniev AS. \newblock {Conformation and mode of membrane interaction in cyclotides. Spatial structure of kalata B1 bound to a dodecylphosphocholine micelle.} \newblock Febs J. 2006;273(12):2658--2672. \bibitem{Lin:1998uz} Lin Y, Nielsen R, Murray D, Hubbell WL, Mailer C, Robinson BH, et~al. \newblock {Docking phospholipase A2 on membranes using electrostatic potential-modulated spin relaxation magnetic resonance.} \newblock Science. 1998;279(5358):1925--1929. \bibitem{Canaan:2002dp} Canaan S, Nielsen R, Ghomashchi F, Robinson BH, Gelb MH. \newblock {Unusual mode of binding of human group IIA secreted phospholipase A2 to anionic interfaces as studied by continuous wave and time domain electron paramagnetic resonance spectroscopy.} \newblock J Biol Chem. 2002;277(34):30984--30990. \bibitem{Lathrop:2001wu} Lathrop B, Gadd M, Biltonen RL, Rule GS. \newblock {Changes in Ca2+ affinity upon activation of Agkistrodon piscivorus piscivorus phospholipase A2.} \newblock Biochemistry. 2001;40(11):3264--3272. \bibitem{Chen:2000vf} Chen X, Wolfgang DE, Sampson NS. \newblock {Use of the parallax-quench method to determine the position of the active-site loop of cholesterol oxidase in lipid bilayers.} \newblock Biochemistry. 2000;39(44):13383--13389. \bibitem{SekinoSuzuki:1996uy} Sekino-Suzuki N, Nakamura M, Mitsui KI, Ohno-Iwashita Y. \newblock {Contribution of individual tryptophan residues to the structure and activity of theta-toxin (perfringolysin O), a cholesterol-binding cytolysin.} \newblock Eur J Biochem. 1996;241(3):941--947. \bibitem{Phillips:2005gn} Phillips LR, Milescu M, Li-Smerin Y, Mindell JA, Kim JI, Swartz KJ. \newblock {Voltage-sensor activation with a tarantula toxin as cargo.} \newblock Nature. 2005;436(7052):857--860. \bibitem{Thennarasu:2005jw} Thennarasu S, Lee DK, Poon A, Kawulka KE, Vederas JC, Ramamoorthy A. \newblock {Membrane permeabilization, orientation, and antimicrobial mechanism of subtilosin A.} \newblock Chemistry and Physics of Lipids. 2005;137(1-2):38--51. \bibitem{Tatulian:2005ja} Tatulian SA, Qin S, Pande AH, He X. \newblock {Positioning membrane proteins by novel protein engineering and biophysical approaches.} \newblock J Mol Biol. 2005;351(5):939--947. \bibitem{Oldham:2005fb} Oldham ML, Brash AR, Newcomer ME. \newblock {Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality.} \newblock J Biol Chem. 2005;280(47):39545--39552. \bibitem{Mathias:2009bj} Mathias JD, Ran Y, Carter JD, Fanucci GE. \newblock {Interactions of the GM2 Activator Protein with Phosphatidylcholine Bilayers: A Site-Directed Spin-Labeling Power Saturation Study}. \newblock Biophys J. 2009;97(5):1436--1444. \bibitem{Jian:2015do} Jian X, Tang WK, Zhai P, Roy NS, Luo R, Gruschus JM, et~al. \newblock {Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1}. \newblock Structure. 2015;23(11):1977--1988. \bibitem{Eisenhaber:1995bd} Eisenhaber F, Lijnzaad P, Argos P, Sander C, Scharf M. \newblock {The double cubic lattice method: Efficient approaches to numerical integration of surface area and volume and to dot surface contouring of molecular assemblies}. \newblock J Comput Chem. 1995;16(3):273--284. \bibitem{Bondi:1964un} Bondi A. \newblock {van der Waals Volumes and Radii - The Journal of Physical Chemistry (ACS Publications)}. \newblock J Phys Chem. 1964;. \bibitem{Kabsch:1983bp} Kabsch W, SANDER C. \newblock {Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.} \newblock Biopolymers. 1983;22(12):2577--2637. \bibitem{Hinsen:2000wia} Hinsen K. \newblock {The molecular modeling toolkit: A new approach to molecular simulations}. \newblock J Comput Chem. 2000;21(2):79--85. \bibitem{Barber:1996iv} Barber CB, Dobkin DP, Huhdanpaa H. \newblock {The quickhull algorithm for convex hulls}. \newblock ACM Trans Math Softw. 1996;22(4):469--483. \bibitem{SciPyOpenSourceS:g1eMLzGE} Jones E, Oliphant E, Peterson P. \newblock {SciPy: Open Source Scientific Tools for Python};. \bibitem{Team:2008wf} Team RDC. {\emph{R: A Language and Environment for Statistical Computing}}; 2008. \bibitem{epitoolsEpidemiolo:dQp6gsqn} Aragon T. \newblock {epitools: Epidemiology Tools. R package};. \bibitem{Touw:2015ff} Touw WG, Baakman C, Black J, te~Beek TAH, Krieger E, Joosten RP, et~al. \newblock {A series of PDB-related databanks for everyday needs}. \newblock Nucleic Acids Res. 2015;43(D1):D364--D368. \bibitem{Humphrey:1996bk} Humphrey W, Dalke A, Schulten K. \newblock {VMD: Visual molecular dynamics}. \newblock Journal of Molecular Graphics. 1996;14(1):33--38. \end{thebibliography}